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Poster C in Poster Session C: Wednesday, August 5, 9:30 – 11:15 am, Kimmel Center, Shorin & Rosenthal Rooms

Hippocampus and Prefrontal Cortex Differentially Shape Memory Responses in Visual Cortex

Aditi Narayan¹, Robert Woodry², Clayton Curtis², Jonathan Winawer²; ¹Yale University, ²New York University

Presenter: Aditi Narayan

Sensory reactivation in early visual cortex occurs during both working memory and long-term memory tasks. We speculated that the control mechanisms originating from higher order brain areas differ between these two types of memory, with the hippocampus exerting more influence on long-term memory and prefrontal cortex on working memory. To test this, we examined fMRI response patterns in the visual cortex during both tasks as a function of response amplitude in the hippocampus and prefrontal cortex. Our results demonstrate a dissociation: hippocampal response amplitude is strongly linked to long-term memory responses in V1, V2, and V3, and prefrontal cortex amplitude is linked to working memory responses in V1.

Topic Area: Memory, Learning & Knowledge Structures